Sickle cell and pruritis
I watched that video. Benadryl plus Dilaudid are apparently common pain management for sickle cell.
So pruritis is anal itching and Benadryl helps with that and Benadryl treats allergic reactions and allergic reactions are promoted by parasitic infections. It's not uncommon for parasitic infections to be specifically in the large intestine like we are seeing currently in the US with Cyclosporiasis.
So if you routinely use Benadryl during sickle cell crisis, I will suggest you may have an infection and should ask for testing for parasitic infections commonly found in the colon.
You could also check for trypanosoma. It is under diagnosed and associated with poverty housing and, as I noted elsewhere, race is a social construct and skin color is a proxy for "probably poor at some point in life" and people with sickle cell fit that profile.
Formulary of Life has photos of fingernails. If you treat something (take antibiotics for example) or drink heavy and your fingernails go to hell, you should be checked for trypanosoma.
Below is stuff I searched and skimmed:
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what is a sickle cell crisis
what is a sickle cell crisis
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AI generated summary
Sickle cell anemia is a genetic blood disorder characterized by abnormal hemoglobin, leading to misshapen red blood cells that can cause severe health complications.
What is Sickle Cell Anemia?
Sickle cell anemia is a form of sickle cell disease (SCD), which is a group of inherited blood disorders. It occurs when a person inherits two copies of the sickle cell gene (one from each parent), resulting in the production of abnormal hemoglobin known as hemoglobin S. This abnormality causes red blood cells to become rigid, sticky, and shaped like a sickle or crescent moon, which can block blood flow and lead to various health issues
wikipedia.org
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Symptoms
Symptoms of sickle cell anemia typically appear around six months of age and can vary widely among individuals. Common symptoms include:
Anemia: Due to the rapid breakdown of sickle cells, leading to fatigue and weakness.
Pain Crises: Sudden episodes of severe pain, known as sickle cell crises, occur when sickle-shaped cells block blood flow to organs and tissues
Swelling: Particularly in the hands and feet, known as dactylitis, which is often one of the first symptoms in infants
Frequent Infections: Sickle cells can damage the spleen, increasing susceptibility to infections
Delayed Growth: In children and adolescents due to chronic anemia and other complications
Vision Problems: Caused by blocked blood vessels in the eyes, potentially leading to retinal damage
mayoclinic.org
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Complications
Sickle cell anemia can lead to serious complications, including:
Stroke: Blocked blood flow to the brain can result in a stroke, with symptoms like seizures and sudden weakness
Acute Chest Syndrome: A life-threatening condition characterized by chest pain, fever, and difficulty breathing
Organ Damage: Chronic lack of oxygen can damage organs such as the liver, kidneys, and lungs
mayoclinic.org
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Treatment and Management
While there is no universal cure for sickle cell anemia, various treatments can help manage symptoms and reduce complications:
Preventive Care: Regular vaccinations and antibiotics to prevent infections
Pain Management: Medications to relieve pain during crises
Hydroxyurea: A medication that can reduce the frequency of pain crises and the need for blood transfusions
Blood Transfusions: To treat severe anemia and prevent stroke by increasing the number of normal red blood cells
Gene Therapy: Emerging treatments aim to correct the genetic mutation causing sickle cell disease, offering hope for a long-term cure
who.int
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Conclusion
Sickle cell anemia is a serious inherited disorder that significantly impacts the lives of those affected. With proper management and treatment, individuals with sickle cell anemia can lead fulfilling lives. Ongoing research and advancements in treatment options continue to improve outcomes for patients with this condition. For more detailed information, resources from reputable health organizations such as the CDC, Mayo Clinic, and WHO can be consulted.
mayoclinic.org
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Cleveland Clinic
https://my.clevelandclinic.org › health › diseases
Sickle Cell Crisis: Symptoms, Types & Treatment - Cleveland Clinic
Aug 29, 2024 · What is a sickle cell crisis? A sickle cell crisis is a painful episode that can occur if you have sickle cell disease. It happens when sickled cells …
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WebMD
https://www.webmd.com › a-to-z-guides
Sickle Cell Crisis: Symptoms, Causes, Treatment, Prevention
Oct 29, 2024 · Sickle cell crisis can be very painful and you never know when it might come on. Learn the symptoms, what to do when you have a crisis, and …
Author: Jennifer Clopton
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Verywell Health
https://www.verywellhealth.com
Sickle Cell Crisis: Types, Causes, Symptoms, Treatment
Jul 17, 2026 · Sickle cell crisis is a health complication of sickle cell disease that usually causes severe pain. Triggers for a sickle cell crisis include infections, …
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scienceinsights.org
https://scienceinsights.org
What Is a Sickle Cell Crisis? Symptoms, Types & Triggers
A sickle cell crisis is an episode of sudden, often severe pain that occurs when misshapen red blood cells block small blood vessels and cut off blood flow to nearby …
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Drugs.com
https://www.drugs.com › cg
Sickle Cell Crisis - What You Need to Know - Drugs.com
Jul 5, 2026 · What is a sickle cell crisis? A sickle cell crisis is a painful episode that occurs in people who have sickle cell anemia. It happens when sickle …
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CDC
https://www.cdc.gov › sickle-cell › complications
Complications of SCD: Pain | Sickle Cell Disease (SCD) | CDC
May 15, 2024 · A pain crisis (vaso-occlusive episode or VOE) can start suddenly, be mild to severe, and can last for any length of time. Pain can occur in any part of …
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Kaiser Permanente
https://healthy.kaiserpermanente.org › health-wellness
Sickle Cell Crisis: Care Instructions | Kaiser Permanente
Sickle cell crisis is a painful episode that may begin suddenly in a person with sickle cell disease. Sickle cell disease turns normal, round red blood cells into cells …
redbloodcellhealth.com
https://www.redbloodcellhealth.com
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sickle cell secondary infections
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Sickle cell secondary infections
Infections are a significant cause of morbidity and mortality in individuals with sickle cell disease (SCD). People with SCD are at a higher risk for infections due to their immune system's compromised state, which can lead to severe and life-threatening complications. The types of infections that commonly affect individuals with SCD include:
Pneumonia: A leading cause of death in infants and young children with SCD.
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Meningitis: Infections of the brain and spinal cord can occur, leading to severe neurological complications.
1
Infections caused by Streptococcus pneumoniae: These bacteria can cause lung infections, ear and sinus infections, and infections of the tissue covering the brain and spinal cord.
1
Respiratory Syncytial Virus (RSV): A common cause of lung and respiratory tract infections, especially in children with SCD.
1
Other viral infections: Such as parvovirus, which can cause severe anemia and other complications.
1
Preventive measures such as vaccination, prophylactic antibiotics, and access to clean water and mosquito avoidance can help reduce the risk of infections in individuals with SCD. However, the high risk of infections remains a significant challenge for those with SCD, necessitating ongoing medical care and support.
2
cdc.gov
Complications of SCD: Infection | Sickle Cell Disease (SCD) | CDC
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CDC
https://www.cdc.gov › sickle-cell › complications
Complications of SCD: Infection | Sickle Cell Disease (SCD) | CDC
Jul 14, 2026 · People with SCD, especially infants and children, are more likely to experience harmful infections, such as the flu, meningitis, and pneumonia. …
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CDC
https://www.cdc.gov › sickle-cell
https://www.cdc.gov/sickle-cell/complications/index.html
Complications of Sickle Cell Disease | Sickle Cell Disease (SCD) | CDC
People with SCD are more likely to have harmful infections, such as flu, meningitis, and pneumonia. SCD can reduce blood flow to the kidneys, leading to kidney damage and chronic kidney disease. Poor circulation of blood in the leg can lead to painful leg ulcers in people with SCD.
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ScienceDirect
https://www.sciencedirect.com › org › science › article › pii
Infections in sickle cell disease - ScienceDirect
Patients with SCD have significant immunodeficiency and are more likely to suffer severe and life-threatening complications of infection, and additionally infections …
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Haematologica
https://haematologica.org › article
Infections in sickle cell disease | Haematologica
Patients with SCD have significant immunodeficiency and are more likely to suffer severe and life-threatening complications of infection, and additionally infections …
sickle cell parasitic infections
sickle cell parasitic infections
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Sickle Cell Parasitic Infections
Sickle cell disease (SCD) patients are at a higher risk for parasitic infections due to their compromised immune system and the presence of sickled red blood cells. Here are some key points regarding SCD and parasitic infections:
Infection Risk: Individuals with SCD are more likely to experience harmful infections, such as the flu, meningitis, and pneumonia. Pneumonia is a leading cause of death in infants and young children with SCD.
1
Vaccination: People with SCD should get all recommended vaccinations, including a flu vaccination. Children under 5 years of age with SCD should receive daily penicillin or other prescribed antibiotics.
1
Infection Complications: Infections can trigger complications of SCD itself, leading to acute chest syndrome, acute painful episodes, osteomyelitis, meningitis, urinary tract infections, overwhelming sepsis, and death.
1
Vaccine Recommendations: The CDC recommends a special vaccination schedule for children under 5 years of age with SCD, including a flu vaccination.
1
It is crucial for individuals with SCD to be aware of their increased risk for infections and to follow the recommended vaccination guidelines to reduce the risk of severe complications.
1
haematologica.org
Infections in sickle cell disease | Haematologica
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Haematologica
https://haematologica.org › article
Infections in sickle cell disease | Haematologica
Sickle cell disease (SCD) causes severe acute complications and chronic illness, driven by vaso-occlusion and hemolytic anemia. 1 A significant part …
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PubMed
https://pubmed.ncbi.nlm.nih.gov
More than malaria: Exploring Babesia, Leishmania and ... - PubMed
Jun 3, 2026 · This narrative review synthesizes current evidence on the relationship between SCD and these parasites, focusing on pathophysiology, immune …
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ScienceDirect
https://www.sciencedirect.com › org › science › article › pii
Infections in sickle cell disease - ScienceDirect
Sickle cell disease (SCD) causes severe acute complications and chronic illness, driven by vaso-occlusion and hemolytic anemia. 1 A significant part …
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National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc
Altered parasite life-cycle processes characterize
In this paper, we examine the impact of both the sickle cell anemia and sickle trait red blood cell (RBC) environment on different aspects of the B. divergens …
DOI: 10.3324/haematol.2018.214304
Publication: Haematologica. 2019 Nov; 104(11): 2189-2199.
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